Acronyms & Abbreviations: First-Use Rules and Style

Acronyms speed up writing — until they slow down readers. The trick is knowing which ones to introduce, which to assume, and how to handle plurals, possessives, and punctuation. This guide covers the rules that hold across AP, Chicago, and MLA style.

Common Style Differences

ItemAP StyleChicagoMLA
U.S. / USU.S. (with periods)US (no periods)US (no periods)
Plural acronymsAPIs (no apostrophe)APIs (no apostrophe)APIs (no apostrophe)
First-use spelloutRequired unless universalRequired for unfamiliarRequired unless universal
"e.g." and "i.e."Avoid in bodyOK with commasOK with commas
Doctor / Mr.Dr., Mr. (periods)Dr., Mr. (periods)Dr. Mr (no period UK)

The First-Use Rule

Spell out the full term, follow with the acronym in parentheses, then use the acronym for the rest of the document: "the World Health Organization (WHO) recommends…". Reset the rule for new sections in long documents — readers don't always start at the top.

Plurals and Possessives

  • Plural: add lowercase 's' — URLs, CEOs, APIs.
  • Possessive: add apostrophe-s — the CEO's announcement, the API's response.
  • Plural possessive: apostrophe after the s — the CEOs' meeting.
  • Never: CEO's as a plural — this is the most common error in business writing.

When to Skip Acronyms

  1. The term appears only once or twice — just write it out.
  2. The audience won't recognize the spelled-out version either.
  3. The acronym is offensive, controversial, or ambiguous in another field.
  4. You're writing for a general audience and the acronym is industry jargon.

Check Your Copy's Clarity

Acronym-heavy text often scores poorly on readability — check yours.

Readability Checker →

Frequently Asked Questions

Acronyms are pronounced as words (NASA); initialisms letter by letter (FBI).
Yes for most acronyms — exceptions for universally known ones like FBI or HTML.
Add lowercase 's' without apostrophe — APIs, CEOs, URLs.
Modern usage drops them in most acronyms; some style guides keep U.S. and Dr.
Spell out on first use even for technical audiences and keep a glossary.